VEGFA and neoplasm: At a critical point in the growth of a tumour, when the “angiogenic switch” is flipped to shift the tumour microenvironment to a pro-angiogenic state, the tumour sends out signals to the nearby endothelial cells to activate new blood vessel growth.3 The vegf family of growth factors and its receptors constitute the most important signalling pathways in tumour angiogenesis4.