In psoriasis, a CNV comprising the β-defensin gene cluster was reported as a risk factor in various European cohorts, including our own study group.60 Iafrate et al36 reported a frequent CNV of the adjacent telomeric region encompassing the 3′ parts of MUC16 gene as well as MBD3L1 and ZNF558 genes. This evidence concerns the gene ZNF558 and psoriasis.