Expression in other epithelia such as ocular surfaces (cornea, conjunctiva), respiratory tract and vagina has been described.45, 46 The highly glycosylated MUC16 has long been known as a tumour marker indicating recurrence of ovarian cancer and preceding cancer genesis47 and is often referred to as antigen CA125.48 Our immunohistochemical analysis revealed weak general staining of the epidermis with focally increased signals in suprabasal cells of the suprapapillary epidermis. Here, MUC16 is linked to ovarian cancer.