Interestingly, retinoids and glucocorticoids, which are effective therapeutic agents in psoriasis, enhance MUC16 expression in eye epithelia.53, 54, 55 Furthermore, a role of MUC16 in protection against pathogen adherence56 renders it an even more interesting gene for psoriasis with regard to the HLA-C risk allele. The gene discussed is MUC16; the disease is psoriasis.