INSIG2 and obesity due to melanocortin 4 receptor deficiency: Although Rosskopf et al. did not observe any association between the INSIG2 variant and either obesity or BMI when the entire Study of Health in Pomerania (SHIP) cohort consisting of 4,310 unrelated German individuals was assessed, a subgroup analysis of 2,701 overweight individuals in SHIP showed that both the mean BMI and risk of being obese was increased for rs7566605 CC homozygotes when compared to those with the GC and GG genotypes.