CREB1 and Hand-foot syndrome: The results showed that HFS-induced increases of p-CaMKII (10 min), p-ERK (10 min) and p-CREB (2 h) protein levels were partly, but significantly reduced by pretreatment of EphB2-Fc (2 μg, covering from 30 min prior to, during and up to 10 min to 2 h after HFS).