During zinc deficiency, the production of TH1 cytokines, in particular IFN-γ, IL-2, and tumor necrosis factor (TNF)-α is reduced, whereas the levels of the TH2 cytokines IL-4, IL-6, and IL-10 were not affected in cell culture models [46] and in vivo [47,48]. Here, IFNG is linked to Zinc deficiency.