Monocyte and macrophage chemotaxis and survival is strongly regulated by the growth factor CSF-1 produced by a variety of cells including fibroblasts, mononuclear phagocytes, and prostate cancer cells [40,41], and reducing intratumoral and systemic CSF-1/CD115 has been shown to suppress breast cancer growth [10,11]. Here, CSF1R is linked to Familial prostate cancer.