TAMs are derived from a minor subpopulation of circulating monocytes [4] and are proangiogenic in tumor regions of hypoxia [5], promoting ECM remodeling by producing matrix metalloproteases, secreting proangiogenic growth factors such as vascular endothelial growth factor (VEGF), and stabilizing the tumor vasculature [6]. The gene discussed is VEGFA; the disease is neoplasm.