KRAS and infection: Assuming that one HCV particle contains about 200 copies of core protein (an estimate that is derived from hepatitis B virus, which has a similar particle size [41]), the (theoretical) infection dose per animal (100 μl inoculum) was about 7.7×107 particles in case of Con1/wt, 2.9×107 particles in case of Con1/K1846T and about 3×106 particles in case of Con1/NS3+K1846T, respectively.