First, we examined the expression of RUNX3 in 14 HNSCC cell lines (HSC2, HSC3, HSC4, Ca9-22, Ho-1-U-1, Ho-1-N-1, ZA, HOC719-PE, HOC719-NE, HOC621, HOC119, HOC313, TSU, and OMI). Here, HMOX1 is linked to head and neck squamous cell carcinoma.