In particular, they reported two variants of AMACR gene (which encodes a-methylacyl-CoA racemase) resulting from the alternative use of the last exon coupled with alternative polyadenylation: one isoform showed a quantitative up-regulation in prostate cancer compared with normal prostatic tissues, the other seemed to be expressed only in prostate cancer. The gene discussed is AMACR; the disease is Familial prostate cancer.