Bodmer and Tomlinson illustrated the relative powers of a selective advantage and an increased mutation rate by the fact that Lynch syndrome patients (with a mutator phenotype due to mismatch repair deficiency) develop about the same number of colorectal adenomas as the general population (although cancers will develop faster), whereas Familial Adenomatous Polyposis (FAP) patients (with germline APC mutations) usually develop thousands of colorectal tumours. The gene discussed is APC; the disease is Familial adenomatous polyposis.