NKX2-5 and myotonic dystrophy type 1: DM1 has been also associated with overexpression of the cardiac-specific transcription factor NK2 transcription factor related, locus 5 (Drosophila) (Nkx2-5), also known in Drosophila as tinman. Levels of NKX2-5 increased in cardiac tissue in a reversible transgenic mouse model for RNA toxicity [43].