DMPK and fragile X-associated tremor/ataxia syndrome: The toxic RNA hypothesis is now a well established model to explain the pathogenic effect of mutant DMPK transcripts and is being extended to other trinucleotide diseases such as Fragile X Tremor Ataxia Syndrome, Spinocerebelar Ataxia 3 (SCA3), or Huntington ́s Disease-Like 2 (HDL-2) among other disorders [86, 95, 96].