Although it was already known that cytoplasmic CUG-BP1 could promote translation of p21 [92], C/EBPβ [93] and Mef2A [70] in differentiating cells by interacting with translation initiation factor eIF2, the mechanism by which translation was inefficient in DM1 muscle cells was not fully understood, in particular after confirming that the levels of CUG-BP1 mRNA did not show any significant change in DM1 muscle cells when compared to normal myoblasts [94]. Here, CELF1 is linked to myotonic dystrophy type 1.