INS and type 2 diabetes mellitus: To date, genetic variation in voltage-dependent Ca2+ channels (CACNA1E) and KATP (KCNJ11) channels have been shown to influence insulin secretion and type 2 diabetes risk [8], [9], and genome-wide association studies (GWAS) for type 2 diabetes in Caucasians have proven the importance of genes coding for proteins involved in insulin secretion [10]–[14].