In this context it is important to notice that polymorphisms in the neighbouring CDKN1C have been associated with increased birth weight [17], and that variation in the CDKN family (CDKN2A/B locus; chromosome 9p21) has been associated with type 2 diabetes in recent GWAS- and GWAS-replication studies [10]–[12], [14], [32]. This evidence concerns the gene CDKN2A and type 2 diabetes mellitus.