In order to further investigate a putative beta cell abnormality, the interplay between insulin release (Insulinogenic index: I/G30), insulin resistance (Homeostasis model assessment of insulin resistance: HOMA-IR) and the genetic predisposition to type 2 diabetes with KCNQ1 rs2237895, we applied the multivariate Hotelling's T2 method to simultaneously test the effect of genotype on I/G30 and HOMA-IR in the sample of glucose tolerant individuals. This evidence concerns the gene KCNQ1 and type 2 diabetes mellitus.