More specifically related to the urinary tract and fibrosis, both Serpine1 and TGF-β1 are involved in diabetic nephropathy [40], and in the context of smooth muscle cells, TGF-β1 protein is involved in expression of human Serpine1 mRNA in smooth muscle cells from myometrium of human females [41]. Here, TGFB1 is linked to diabetic kidney disease.