HLA-E and Hutchinson-Gilford progeria syndrome: Among the age-induced genes were: laminin A (LMNA) that is mutated in Hutchinson-Gilford progeria [21], [23]; the glycoprotein clusterin (CLU) that plays a role in apoptotic cell death and aggregates within plaques in the brains of Alzheimer's patients; CD44; annexins ANXA1, ANXA2 and ANXA3; the homeobox genes HOXA7, HOXB5, HOXB6 and HOXB7; and a remarkable over-representation of genes involved in major histocompatibility complexes (HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DRB3, HLA-DMA, HLA-E and HLA-F) that has also been described for aging of murine leukocytes [24], [25].