SHOX2 and Hutchinson-Gilford progeria syndrome: Among the up-regulated genes were: mesenchyme homeobox 2 (MEOX2) that functions as a negative regulator of proliferation in several mesodermal tissues and that is most affected in fibroblasts of patients with Hutchinson-Gilford progeria syndrome [21]; short stature homeobox 2 (SHOX2) that is thought to be responsible for idiopathic short stature [22]; and HOXC6, which is part of a developmental regulatory system.