STRADA and polyhydramnios, megalencephaly, and symptomatic epilepsy: Recently, it was reported that a severe human developmental and epileptic syndrome termed polyhydramnios, megalencephaly, symptomatic epilepsy (PMSE), was caused by a homozygous partial deletion in the STRADα gene (LYK5), truncating 180 C-terminal residues of the protein [14].