On the basis of genomic data of a previous study, the hierarchical cluster analysis dendrogram of the 219 genes with the highest prognostic information in 252 N+ breast cancer patients showed a direct link between 2 proteasome subunit genes located in 17q12 and ERBB2 locus, known to be a hot spot of gene amplification in breast cancer. The gene discussed is ERBB2; the disease is breast cancer.