The ANX2 is not observed in normal hepatocytes, the pancreatic exocrine system and the mammary gland (Frohlich et al, 1990; Dreier et al, 1998; Massey-Harroche et al, 1998); in tumours that arise from these tissues, such as hepatocellular carcinoma, pancreatic cancer and breast cancer, respectively, ANX2 expression is observed as membrane and/or cytoplasmic staining (Frohlich et al, 1990; Diaz et al, 2004; Sharma et al, 2006). This evidence concerns the gene ANXA2 and breast cancer.