As for the role in cancer, it is reported that overexpression of ANX2 is associated with progression and metastasis in various types of cancer, including brain tumour (Reeves et al, 1992), pancreatic cancer (Diaz et al, 2004; Esposito et al, 2006), gastric cancer (Emoto et al, 2001a) and colorectal cancer (Emoto et al, 2001b). Here, ANXA2 is linked to colorectal cancer.