Upregulation of ANX2 expression has been reported in hepatocellular carcinoma (Frohlich et al, 1990), lung cancer (Cole et al, 1992), pancreatic cancer (Diaz et al, 2004; Esposito et al, 2006), breast cancer (Sharma et al, 2006), gastrointestinal cancer (Singh, 2007), glioma (Reeves et al, 1992) and colorectal cancer (Emoto et al, 2001b). The gene discussed is ANXA2; the disease is central nervous system cancer.