TP53 and hepatocellular carcinoma: Besides, Shieh et al. 2003 [45] reported that emodin or 1,3,8-trihydroxy-6-methyl-anthraquinone displays effective inhibitory effects on the growth of various human hepatoma cell lines and stimulates the expression of p53 and p21 that resulted in the cell cycle arrest of HepG2/C3A cells at G2/M phase.