Inhibition of HO-1 activity by ZnPP boosted anticancerous effects of gemcitabine resulting in significant reduction of tumor growth in gemcitabine treated mice with PANC-1 tumors (-59.26 ± 15.32%) (P < 0.05) as opposed to gemcitabine treated tumors only (-43.61 ± 15.12%). Here, HMOX1 is linked to neoplasm.