Although only a few of these partners have been examined at the molecular level, it is well known from FISH studies that the breakpoints may occur inside as well as outside HMGA2. Thus, it was not unexpected that all five lipomas with variant 12q13-15 rearrangements in the present study, representing five different recombination partners, showed overexpression of HMGA2 and that some of them had expression of the full-length gene whereas others had differential expression. This evidence concerns the gene HMGA2 and lipoma.