The only analyzed lipoma with a translocation involving 6p21-22 and two angiolipomas had normal signals for HMGA2. Four atypical lipomas with ring chromosomes showed amplification of HMGA2, with more copies of the 5'-end than of the 3'-end; intact signals were consistently found on the normal chromosomes 12 (Figure 2B). Here, HMGA2 is linked to lipoma.