In the present study, we used fluorescence in situ hybridization (FISH) and quantitative RT-PCR (qRT-PCR) to study the genomic status and expression level of full-length and truncated HMGA2 in various adipocytic tumors, including conventional lipomas, angiolipomas, spindle cell lipomas, hibernomas, atypical lipomas, well-differentiated liposarcomas, and myxoid liposarcomas. The gene discussed is HMGA2; the disease is spindle cell lipoma.