Notch signalling has also been shown to inhibit apoptosis in developing thymocytes and in T-ALL cells through a variety of mechanisms: At the protein level, Notch activates the NF-κB pathway [3,12], and activates the PKB/AKT/mTOR pathway-mediated p53 inhibition [13]. Here, AKT1 is linked to acute lymphoblastic leukemia.