AGE such as CML can be formed by different processes including glycation followed by oxidative cleavage of Amadori-adducts, auto-oxidative glycosylation, reaction of proteins with non-glucose carbohydrates, lipoxidation, and by reaction of proteins with products of MPO derived from neutrophils [30-33]. The gene discussed is MPO; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.