Other MUTYH variants found in noteworthy allelic frequencies in characteristic populations are: c.1145delC (found in Italian MAP patients in allelic frequencies of 0.07-0.11 [65, 66]), A473D (found in Finnish Polyposis and CRC patients, in the latter group with an allelic frequency of 0.01 [67]) and E383fsX451 (found in Portuguese MAP patients with allelic frequencies of 0.15-0.19 [68, 69]). Here, MUTYH is linked to mutyh-associated polyposis.