No significant association was detected from gene-environment (smoking, alcohol) interaction meta-analysis, despite the biological plausibility, while an OR of 5.36 (95%CI: 1.01-28.47) for gastric cancer appeared for CYP2E1 c2 homozygotes with GSTM1 null genotype, compared with individuals carrying both wild-type genotypes. This evidence concerns the gene GSTM1 and gastric cancer.