Though hippocampal BDNF expression was not influenced with wheel running behaviour (a model of learned helplessness) in rats [101], increased BDNF and decreased 5-HT turnover was observed in frontal cortex and hypothalamus in olfactory bulbectomised mice, a sensitive rodent model of hyposerotonergic depression [121]. The gene discussed is BDNF; the disease is depressive symptom measurement.