In vivo histopathology of the LCA5 patients was compared to a group of patients with retinal degeneration and similar foveal ONL thickness, and who had been found, by dark-adapted chromatic perimetry, to be at a stage of disease that had reduced vision to a central island with only abnormal cone function [41] (Figure 2B-D). The gene discussed is LCA5; the disease is retinal degeneration.