CACNA1G and type 2 diabetes mellitus: As well as IRS1, genes in the T2DM KEGG pathway in selected regions included CACNA1G (calcium channel, voltage-dependent, T type, alpha 1G subunit) and CACNA1E (calcium channel, voltage-dependent, R type, alpha 1E subunit) within which polymorphisms have been linked with T2DM [42].