FOXC2 and hypoplastic left heart syndrome: We show that patients with deletions harboring FOXF1 and the neighboring FOXC2 (MIM 602402) and FOXL1 (MIM 603252) genes at 16q24.1 have not only ACD/MPV, as expected, but also distinct malformations comprising congenital heart defect, in particular hypoplastic left heart syndrome, and gastrointestinal atresias, including esophageal atresia, as well as urinary tract malformations and other malformations.