We propose that patients with intestinal atresia, isolated diastasis recti, or umbilical hernia should be screened for mutations and deletions in FOXL1. Given that FOXF1 maps only ∼3.7 Mb from 16qter, we also suggest that a balanced rearrangement involving 16qter (e.g., submicroscopic subtelomeric reciprocal translocation) should be excluded in parents with an ACD/MPV-affected child from whom no material is available for testing. This evidence concerns the gene FOXL1 and Umbilical hernia.