FGFR4 and breast carcinoma: Furthermore, SNP rs351855 located in exon 9 of the FGFR4 gene results in an amino acid change (Gly388Arg) in the transmembrane domain of the receptor and has been associated with tumor progression in, for example, cutaneous nodular malignant melanoma, breast cancer, lung adenocarcinoma, prostate cancer, and head and neck cancer [26,31-36].