We conducted a nested case-control study of Caucasians within the Nurses' Health Study (NHS) to evaluate whether the four breast cancer-related SNPs in the FGFR2 gene (rs11200014, rs2981579, rs1219648, and rs2420946) [24] and the three common variants (tag-SNPs) in the FGFR4 gene (rs1966265, rs376618, and rs351855) are associated with the risk of three skin cancer types including melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC). This evidence concerns the gene FGFR4 and squamous cell carcinoma.