As shown in Fig 4A, on day 22 after tumor cell inoculation, PEDF level in Ad-PEDF group was significantly higher than control groups, 77.36 ± 3.78 ng/ml vs 33.62 ± 2.79 ng/ml in Ad-null and 36.87 ± 3.35 ng/ml in NS groups, respectively (p < 0.05). This evidence concerns the gene SERPINF1 and neoplasm.