Therefore, these results suggest that neutralising TNF alone might block the migration of memory B cells into the synovium without a persistent effect on T cell trafficking, which support recent findings showing that in RA patients with disease remission after anti-TNF therapy (using either specific TNF blockers or simultaneous blockade of TNF and LTα) the number and the density of B cells in the synovial membrane and the frequency of ectopic germinal centres significantly decreased [5]. The gene discussed is TNF; the disease is rheumatoid arthritis.