Neutralising TNF in RA diminishes the production of pro-inflammatory cytokines in the joints, lowers the levels of circulating IL1, IL6 and acute-phase proteins [22,25], and decreases the serological levels of ICAM-1, ICAM-3, VCAM-1, VEGF and E-selectin [57,58]. This evidence concerns the gene ICAM3 and rheumatoid arthritis.