Our present study has demonstrated that in NPC asides from the difference in drug sensitivity to G418 and expression of surface HLA class II (Table 1), the baseline and response profiles to IFN-γ transduction of IL-6 and IL-6Rα are also found to be different between cultured P-NPCs and BM-NPCs. The gene discussed is IL6R; the disease is nasopharyngeal carcinoma.