The identification of an expanding role for IFN-γ in the phenotypic changes favouring for improved immunogenicity of neoplastic cells prompted us to search for soluble or cell bound molecules associated with NPC malignant cells, in addition to certain important molecules required for immune recognition, such as ICAM-1, HLA class I and HLA class II already documented in many cancer systems. Here, ICAM1 is linked to nasopharyngeal carcinoma.