LMNA and hepatocellular carcinoma: However, two reports (Leiriao et al., 2005; van de Sand et al., 2005) have also presented evidence that P. berghei-infected HepG2 cells (another human hepatoma cell line) and infected mice hepatocytes in vivo are highly resistant to apoptosis, as assessed by a lack of caspase activation and lamin and DNA degradation, induced by peroxide and tumour necrosis factor treatment [which, incidentally, also induce VRAC activity in HeLa and HTC rat hepatoma cells (Shimizu et al., 2004; Varela et al., 2007)].