Given the recruitment of histone acetyltransferases by Myc proteins, particularly GCN5 [35] and the dependence on N-Myc for widespread maintenance of AcK9, another key euchromatic mark, in neuroblastoma [29], it is somewhat surprising that decreased N-Myc levels would be accompanied by increased acetylation at these specific genes. The gene discussed is MYCN; the disease is neuroblastoma.