In order to (a) gain a better understanding of the frequency and nature of TSG methylation in RCC and (b) compare the patterns of CpG methylation in TSGs from papillary RCC and cRCC with and without VHL inactivation, we analysed RCC samples using a high-throughput CpG methylation analysis platform (Illumina Goldengate Assay). Here, VHL is linked to renal cell carcinoma.