However, although evidence for preferential methylation of genes within a specific chromosome region has been reported in colon cancer [17], HOXA11 and HOXC6 map to 7p15-p14 and 12q13.3 respectively and so their preferential involvement in papillary RCC presumably reflects their related functions rather than their cytogenetic location. This evidence concerns the gene HOXC6 and colonic neoplasm.