Euclidean cluster analysis for 260 genes showing tumour-specific methylation was performed (this analysis used quantitative methylation index data) and there was significant evidence of clustering of tumour types (comparing VHL and non-VHL tumours (Fisher exact P = 0.00042) and using all three types χ2 = 13.3, df = 2, P = 0.0013) (see Figure 2). Here, VHL is linked to neoplasm.