However, although evidence for preferential methylation of genes within a specific chromosome region has been reported in colon cancer [17], HOXA11 and HOXC6 map to 7p15-p14 and 12q13.3 respectively and so their preferential involvement in papillary RCC presumably reflects their related functions rather than their cytogenetic location. The gene discussed is HOXC6; the disease is malignant colon neoplasm.