One frequently methylated gene was significantly more frequently methylated in VHL-associated cRCC than in wtVHL sporadic cRCC: GABRB3 (48% vs 20%; log-likelihood G-test, p < 0.05; a less stringent p-value was used due to the lower overall frequency of methylation in the VHL subgroup). The gene discussed is GABRB3; the disease is chromophobe renal cell carcinoma.