MLH1 and colorectal cancer: However, using an unbiased approach to defining putative CIMP-related markers, Weisenberger et al (a) provided evidence for CIMP+ colorectal cancer and (b) demonstrated that CIMP+ sporadic colorectal cancers were associated with the presence of a BRAF mutation and microsatellite instability (from MLH1 promoter methylation) (12).