In most cases (37/43 genes), methylation was more frequent in cell lines than primary tumours, however for 6 genes this pattern was reversed (ZNF215: 21% and 42% respectively, DAPK1: 4% and 39%, EPHA3 13% and 32%, SMARCB1: 8% and 27%, EPS8 4% and 21% and MCM2: 0% and 21%). This evidence concerns the gene EPHA3 and neoplasm.