In addition, neoplastic cells of intratubular germ cell neoplasia (IGCN), adjacent to seminoma and embryonal carcinoma, revealed a positive ERβ1 and ERβ2 immunostaining (Fig 2: A1, A2, B1, B2) but no ERα immunoreactivity (data not shown). The gene discussed is ESR1; the disease is embryonal carcinoma.