Since compound B2 does not interact directly with huntingtin or α-synuclein, its cytoprotective effects may be pleiotropic and unrelated to inclusion body formation, analogous to the protective role of heat-shock protein Hsp27, which shows indirect activity in modulating huntingtin aggregation but a more fundamental role in antagonizing caspase activation and apoptosis in HD models [69]. This evidence concerns the gene HTT and Huntington disease.