HTT and Huntington disease: Elevated toxicity is reported in several HD models after stimulating aggregation through such means as chaperone depletion [56], [57], dopamine exposure [58], inhibiting autophagy [59], expressing anti-polyglutamine recombinant intrabodies [60], depleting normal cellular prion protein [61], or overexpressing specific huntingtin-interacting proteins such as intersectin or normal repeat-length huntingtin fragments [62], [63].