In addition, some of the pathophysiological features of PD were also found in PINK1-deficient mice: (i) the reduced dopamine content of the striatum; (ii) the altered expression of α-synuclein mRNA; (iii) a mitochondrial dysfunction that is bound to result in the enhanced oxidative stress susceptibility previously published for Pink1−/− mice [14]. The gene discussed is PINK1; the disease is Parkinson disease.