If the IVS2-2A>G variant was in fact associated with hearing loss in humans, based on the carrier rate of 4.1% observed among Caucasians, the contribution to hereditary hearing loss in humans of this SLC26A5 variant could reasonably be expected to be greater than that of mutations in GJB2, encoding Connexin 26, which have a carrier rate among Caucasians of approximately 3% [24]. The gene discussed is SLC26A5; the disease is hearing loss disorder.