Although multiple factors contribute to fungal virulence, including the expression of extracellular proteases, morphogenic switching, adherence, hydrolytic enzymes, and capsule production, the conserved ability of fungal pathogens to subvert the host plasminogen system suggests that plasminogen binding may be an additional mechanism used by fungi to promote dissemination and tissue invasion during infection [27], [46], [48], [88], [89]. This evidence concerns the gene PLG and infection.