Glucose-regulated protein 78 may confer resistance against adriamycin- and etoposide-mediated apoptosis in cancer cells through inhibition of Bax and caspase-7 activation (Reddy et al, 2003; Davidson et al, 2005; Ermakova et al, 2006; Lee et al, 2006; Ranganathan et al, 2006). The gene discussed is BAX; the disease is cancer.