Although expression of UHRF1 was not associated with difference of gender, numbers of tumour, tumour size, growth pattern (papillary or solid), incidence of recurrence, survival status after 5 years from surgery, and smoking history (P>0.05, Mann–Whitney's U-test, Supplementary Figure 1), we found that the expression of UHRF1 correlated with stages (pTa–pT4) and grades (grades I–III) (Figure 4A and B). This evidence concerns the gene UHRF1 and neoplasm.