The expression of LHRH receptors in tumors is associated with activation of the human EGFR and thus, activated EGFR phosphorylates, a 60kD protein that corresponds to the LHRH receptor.[30] Moreover, in colon adenocarcinoma LHRH binding sites other than the pituitary LHRH receptor may be involved in binding LHRH analogs.[31] Indeed, LHRH receptors are expressed more strongly in tumors than in normal cells.[32, 33] These results suggest that LHRH analogs may bind to the LHRH receptors present in the tumor cells. Here, GNRH1 is linked to colon adenocarcinoma.