In our results we found that SOD and CAT enzymes were up-regulated in R-NMO patients compared to HC (probability for the difference to be over 0 of 0.987 for SOD and 0.974 for CAT) suggesting the activation of a detoxification feedback mechanism in turn to abolish the excess of superoxide radicals as a result of the CNS inflammatory process (Figures 2E and 2F). The gene discussed is SOD1; the disease is neuromyelitis optica.