Serum levels of TNF-α, IFN-γ, IL-10, MMP-9 metalloproteinase, its inhibitor TIMP-1 and OS markers: malondialdehyde, advanced oxidation protein products, peroxidation potential, superoxide dismutase, catalase, and total hydroperoxides from R-NMO patients and healthy controls (HC) were measured. This evidence concerns the gene CAT and neuromyelitis optica.