Therefore, this novel transgenic mouse model may serve as a platform to study the basic mechanisms that underlie cardiac remodeling which are Hp genotype dependent and to search for interventions aimed to modulate this process and attenuate the rapid progression of heart failure and decrease the high mortality rate after MI in Hp 2-2 DM individuals which make up 40% of the DM community. The gene discussed is HP; the disease is myocardial infarction.