In the tumor microenvironment, recruitment of MSCs to tumor cells was associated with elevated expression of proinflammatory molecules such as interleukin-(IL) 6, IL-8, and monocyte chemoattractant protein-1, which may be mediated by the activation of urokinase plasminogen activator and its receptors on human tumor cells [13]. The gene discussed is PLAU; the disease is neoplasm.