In children aged from 6 to 12 years and 11 months, those with acute rhinosinusitis had serum CD4+ T lymphocyte counts on average 173.3 ±42 x 10-9cell/L above the count of similarly aged children without acute rhinosinusitis (p < 0.001); children with chronic rhinosinusitis had CD4+ T lymphocyte counts on average 154.2 ±39 x 10-9cell/L below the count of similarly aged children without chronic rhinosinusitis. Here, CD4 is linked to chronic rhinosinusitis.