Since glycoprotein processing by the endoprotease S1P is not only critical for virus infectivity of LASV [23], and other arenaviruses causing hemorrhagic fever [33], but also for members of the Bunyaviridae family [36], further optimization based on our findings could lead to a potent and specific S1P inhibitor with the potential treatment of certain VHFs. The gene discussed is MBTPS1; the disease is hemorrhagic fever.