Other cancer-related genes at 20q include E2F1, which is specifically targeted by hrHPV-mediated degradation of pRb, PIGU, which may play a role in cell cycle control and was identified as an oncogene in bladder cancer [29], and DNMT3B, a de novo DNA methyl transferase. The gene discussed is DNMT3B; the disease is urinary bladder carcinoma.