The level of adhesion of the three cancer cell types was statistically different on both the CXCL12-treated and untreated endothelium (Figure 3C) (p<0.05) with the adhesion of 231-CXCR4 and 231-CXCR7 cells being significantly greater than 231-control cells (p<0.05). This evidence concerns the gene ACKR3 and cancer.